Stanford researchers develop cancer 'vaccine' that wipes out tumors in mice

Stanford researchers develop cancer 'vaccine' that wipes out tumors in mice

Stanford researchers develop cancer 'vaccine' that wipes out tumors in mice

Stanford's formula contains two immune-stimulating agents which were so effective they eliminated the tumors they were injected into as well as reduced the tumors in untreated parts of the mice.

Levy said the procedure "uses a one-time application of very small amounts of two agents to stimulate the immune cells only within the tumor itself".

It's also unlikely to cause adverse side effects often seen with other immune stimulation, according to researchers.

Scientists at Stanford University's School of Medicine have announced that tests of their new treatment for cancer successfully wiped out all of the tumors in a group of mice. "We're attacking specific targets without having to identify exactly what proteins the T-cells are recognizing".

Researchers are now recruiting lymphoma patients to test the technique in a clinical trial.

However, the cancer did recur in three of the animals, but the tumours later relapsed after another round of immune treatment.

"In the mice, we saw fantastic, bodywide effects, including the elimination of tumors all over the animal", he said.


The treatment takes only one-millionth of a gram injected into the tumorous area which reactivates cancer-specific T-cells in the human body.

The researchers believe the vaccine can serve as cancer therapy.

Similarly, recently approved cancer treatments, like auto T-cell therapy-while proven to be successful-comes with difficult-to-handle side effects as well as an extremely high cost.

"When we use these two agents together, we see the elimination of tumors all over the body", said Levy.

The boosters reinvigorated the T-cells, allowing the cells to destroy the tumors and related cancer that had metastasized throughout the mice.

The vaccine worked on laboratory mice with transplanted mouse lymphoma tumors in two sites on their bodies. A clinical trial was launched in January to test the treatment in patients with lymphoma. If successful, Levy believes the treatment could be useful for many tumor types in humans.

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